Commonly used as a word for "For Sure" or Yes I Agree fully.
Cracker1: Yoh! I'd tap that ass anyday.
Wannabe Cracker: Fo' Sho!
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A shot to the head.
It is said in the tv show Gangland when Do was describing a way to do a hit.
"We had a, uh two guys, we called them Double Trouble. One person would hit you in the body, which would drop you, and the other person would put the what we call the fo' sho'."
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"You comin to dat big partay tonight ma brutha?"
"Yeahh fo sho dawg!"
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That one incredibly hard part in Love Rap in Rhythm Heaven Fever that makes you want to throw your Wii Remote at the goddamn TV.
"Dude, what happened?"
"I lost to the fo' sho' part."