To get belligerently drunk, to the point of blacking out and making choices you may regret
Anyone want to go get knuckled up at Applebee’s with me?
1👍 1👎
The Act Of Whupping Someone's Ass!
BITCH All In My FACE We Bout 2 KNUCKLE UP In Did Bitch!!!
9👍 46👎
To masturbate
The act of masturbation
Guy 1: Did you see Stacey?
Guy 2: Yeah, total nipple slip! I'm totally going to knuckle up to that later
4👍 21👎
When two men choose to engage in mutual masturbation, implementing a "thumb war" grip and jerking themselves off simultaneously, locked at the knuckles.
Since he had a girlfriend, the young man decided to knuckle up with a buddy.