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If you would just loosen your goose dude, you'd feel much better.
The act of taking a shit.
I was constipated for a couple days until today when I loosened up the flow. Man that felt great!
When someone's really uptight and generally being a humorless or overstudious person, you'd say this to them to indicate that they need to relax and take themselves less seriously sometimes. A kinder alternative to get over yourself.
"Why would you play that game? It's so violent and misogynistic!"
"Wow, what are you my mom? It's just good mindless fun, loosen your collar. Damn!"
An "ebonics" term reffering to taking one's clothes off in preparation for "explicit activities".
Hey Chimp, loosen up my buttons. *provocative wink*
Live life to the fullest ; Not holding back. Or used when your friend is being a uptight bitch
Hey Emily you have to live laugh loosen up a bit and stop being so uptight in class
When I'm feeling Naughty, I tend to let loose and start Loosening for the Crew