Adultery:
Your significant other is having sex with someone else.
In Muddy Waters "Long Distant Call" or in Koko Taylor "Evil" The line Another Mule is Kicking in Your Stall refers to being cheated on.
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When a woman is doing a hand-stand while both kicking him in the eyes and giving him a blowjob until completion
“I have black eyes because my girlfriend gave me a cross-eyed mule kick!” - the cross-eyed mule kick