Term originated in the movie/game Tron when a powerful character is done speaking. Used in IRC sometimes as a quit message.
MCP: You will find those programs.. or else
Flunkie (cringing): Yes.. sir..
MCP: This is your final chance.. do not fail me again. End of line.
-OR-
Foo has quit IRC: Quit (End of line)
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euphemism for a bowel movement.
"Hey, you wanna go grab a drink?"
"Alright, but I gotta crap first. The brown train has reached the end of the line."
Steve: im with you till the end of the line.
Bucket: :D
Steve: JUST JOKING ANYWAY IM GONNA LEAVE YOU TO FUCK A 40s CHICK, GUESS THIS IS THE END OF THE LINE.
Bucket: ... :/
When a girl moans so loud that she starts squirting cum from her Pussy. Shen then raps her arms around your dick then pulls her head into your ass hole and chockes on your shit.
Yhea my girl was at the End of the line last night.