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The feeling you get when you have received so many alerts or notifications that you no longer care.
She could be experiencing alert fatigue and is ignoring anything at this point that hits her phone.
When you're tired of hearing Drake music, because there's so much Drake music.
Dylan: Yo, did you hear Drake's dropping a new album?!
GuzzbarGetEm: Who cares....I still haven't even finished listening to Scorpion.
Dylan: Oh shit, sounds like you got Drake fatigue.
When the human body experiences fatigue, caused by having a lot of sex.
My girlfriend and I had sex 30 times last night and now I got sex fatigue.
The hangover of listening to music.
I was listening to a lot of music last night so I got ear fatigue.
When you are doing late night raiding and you feel really tired, uncomfortably warm, and a little sickly. Normally attributed to WoW.
"Bob stayed up late on WoW and got raider's fatigue... he looked like shit just before crawling into bed."
When one gets tired from excessively pooping.
My stomach virus has given me explosive diarrhea, and now I have fecal fatigue.
Skype fatigue occurs when one grows so weary from the lack of physical contact in a long distance relationship that one begins to resent Skype as though it were responsible.
On her 100th day apart from Darren, Amy developed a case of Skype fatigue and spent the entire day in bed, sobbing, completely unable to even look at her laptop.