Being heavily under the influence of drugs or alcohol
Yeah bro your eyes are so red, i can tell you are deep in the bayou
When the tip of the penis is inserted into the vagina, or ass, balls deep.
That part of the ghetto that white people still avoid. I.e Brownsville Brooklyn. May also be used to describe a thuggish individual.
Extra ghetto.
Van may be ghetto but Raquel , she deep ghetto .