When using marijuana you or another person doing something dumb,crazy,stupid or slightly funny
"Bruh watch this"
(Does a flip and falls)
"Oh shit your a tweaker bruh"
"Chill bruh im good"
Tweaking-Smacked ,High asf,doing dumb/funny stuff
Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.
Look at the tweakers peeking out of the blinds.
Look ! That tweakers been down this aisle 17 times in 2 minutes.
Is a person that's looking for something that isn't there.
The tweaker was looking for the bit of crack that he had already smoked.