An infection obtained via sexual means.
Dude 1: Why are you wearing your glasses? Usually you wear contacts.
Dude 2: I gave myself an eye infucktion.
Dude 1: How's you manage that?
Dude 2: I was beating my meat and it got in my eye
When a part of the human body is so infected that it may require ridiculously strong rounds of antibiotics - or perhaps even be considered for removal - then it’s actually infuckted.
Jim’s asshole was so sore, he knew it just had to be infuckted again.