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When a man is being annoying, rude, angry, or grumpy he's got "little chromo syndrome" because the Y chromosome is tiny compared to the X.
"oh god, he's totally got little chromo syndrome"
A little bitch that gets no women
Bo ur such a little dogg you haven’t had a girl friend
The act of going up to a man named Hunter and pinching the tip of his penis
Hey it’s Hunter! Give him a “little woody”
Someone close to you whom you adore, but don't have the courage to tell him/her how much they meant to you. Hence using 'little shit' as a cover to hide your feelings towards them.
"You are very important to me, and I love you, you little shit..."
it means someone watching you, bro
"I just noticed the little webcam light on my laptop turned on without me turning it on myself, must be the little light on my computer. shit i hope i'm ok, hide the weed"
an alternative to saying the "glow" term which some find offensive
"shit it's the little light on my computer again bro!"