Mo' Fucka is a shortened term for motherfucker. Simple as that. Most commonly used in ghetto places; by people who use exessive amounts of slang.
That stupid Mo' Fucka!
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like hella good, only better.
That tray of brownies looks fucka good!
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One who has sex with their mother
You mutha fucka
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This term is simply taking the word mother and saying it in Spanish and adding the slang word for fucker at the end. This is obviously a spin off of mother fucker, but it is just a funnier way of saying it.
"What in the shit suck is happ'nin' madre' fucka?"
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The act of anal sex usually referring to a gay man
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The greatest man ever to exist on this planet...Samuel L Jackson
Samuel L Jackson is one bad mutha fucka
If you can get laid at a sausage fest like MTU, you're one bad mutha fucka
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"Look at james over there mean muggin that dude."
"Yeh dude James is one Salty Motha Fucka"