lay one out

To drop a deuce, dump a load, or otherwise take a crap.

After finishing all that Mexican, I had to lay one out.

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squeeze one out

v. to masturbate, or cause ones self to ejaculate

I squeezed one out in the shower last night.

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Knocking one out

A northern slang term for masturbation. To play with oneself, or toss oneself off.

"I'd love to come with you, but I'm in the middle of knocking one out"

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rub one out

masturbate. The "one" is an orgasm, i.e. rubbing one's genitals to the point of climax. May also refer to a handjob or fingerbang, or more generally, any manual manipulation of genitals.

I got so excited watching her video that I had to rub one out.

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pump one out

To take a fast shit.

I'll catch up with you guys, I just need to pump one out.

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smoothing one out

To "smooth out" one's erection
To masturbrate as a male
To jack off

So I was in my room smoothing one out when my mom walked in...

throw one out

When a male ejaculates, he is throwing some swimmers out.

I was watching some porn last night so I had to throw one out.