Out Of OFFice or Out Of Facility. Used in companies to indicate that an employee will not be in the office at a particular time/day. Commonly used at Microsoft, but also used in other businesses and industries.
"James is OOF on Friday, so let's set the meeting for Thursday afternoon."
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A response along the lines of "oh geez" or facepalm.
Alexandria: Mom just got arrested for riding her bike outside during a quarantine.
Matt: oof
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oof can be used as a term to express interest, while not being interested in the topic at all.
in other words, the most useful word in the english vocabulary.
1: my grandma got hit by a car today.
2: oof.
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The sound you make when you die.
Oof! I got stabbed in the chest!