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It is slang for Meth but not cause what it does to your head. It is because when the smokers exhale a large cloud they sometimes unintentionally make the noise "Boooooooof". It is also a verb for smoking meth.
"I just got some Boof. Do you want to Boof?"
"Sure."
"Boooooof"
Big and oof combined, also known as double oof, fat oof, oof squared etc..
"Hey man I just lost my wallet"
"Boof man boof"
A way of saying stupid like the word doofus
You BOOF the hell are you doing.
This is supposed to trick thomas
Thomas Bailey is one boof ass hoe
Meaning, something was terrible or lame.
That party was boof, no one was there.