Reassuring a friend.
-Hey, you sure this where those bitches s'pose to be?
- Fo shizzle my nizzo
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"Hey come see this".....response: "Fo' shizzle my nizzo"
For sure, my nigger. (Yes, "nigger"! You've been saying this over and over thinking it sounds funny, and all this time you've been saying a racial slur! No wonder all the girls hate you!)
More definitions at "fo shizzle my nizzle".
Ain't that girl tough?
Fo shizzle my nizzle
Term of endearment, ackgnowledging a good idea or act. Ebonics for "for sure my n***er".
"You wanna go rob some white kids?"
"fo shizzle my nizzo"
An statement expressing agreement with another person.
"Wanna go to the store?"
"Fo shizzle my nizzo!"