DOE might be the acronym for Doesn't Officially Exists.
-Who's John Doe?
-We don't know yet.
"Doe" is a shortening of the word "though" and is normally placed at the end of a sentence. It is often used to cancel out or combat what someone else has just said, that you may not agree with. "Despite all else" is another good example of why someone would use the word "doe".
Sam: That girl you're talking to isn't cute.
Tyler: Well she has a nice ass doe.