When one of your friends is being a total asshole to everyone around him, because he has had a fight with his girlfriend. Derived from the popular rap song 99 problems by JayZ. "I got 99 problems but a bitch ain't one"
Stephen: Hey, what the fuck is Stu's problem today?
Pete: He's got 100 problems.
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a way to say you have girl problems. it is a reference to the Jay-Z song, 99 problems
Guy 1: How are you and your girl doing?
Guy 2: Let's just say i got 100 problems
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