The main point of failure on the original version of the Nintendo Entertainment System (NES-001). The pins wear out and bend over time because of bad design and will almost certainly need replaced on any NES-001 console. A worn 72-pin connector will often result in major glitches, failure to read game cartridges, and indirectly, the flashing red light issue.
I can't get Super Mario Bros. 3 to load! Must be the 72-pin connector.