1. Euphemism used to describe and/or add emphasis as to how bad a situation may be.
2. A bad rash. Swelling and redness and I some cases itching and chaffing of the skin of an impacted area of the body.
My boss is like a bad rash. Always on my ass and driving me nuts.
I have a bad rash on my taint. I haven’t bathed for several days and it’s getting a tad itchy.