as serious as cancer

something extremely serious, like cancer

Brittany: Hey! I just crashed my car into a ditch!
Joe: Are you serious??
Brittany: As serious as cancer!

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I'm as serious as dick cancer

The term "I'm as serious as dick cancer" is a response from one guy when asked by another guy if they are serious.

Person 1- Are you serious????

Person 2- I'm serious, bro! I'm as serious as dick cancer"!

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