When one womans breast is larger than the other.
Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome
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When a woman has one breast larger than the other.
Amy is getting a boob job to cure her biggie smalls syndrome.
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A female consisting of a fat ass and no tits.
"Hey Ricky, dating that chick that has Biggy Smalls Syndrome will ultimately lead to your downfall."
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