A "Skittles bitch" is a man who uses the colored candy shells of Skittles as make-up in prison. They soak the candies to soften them and then paint their faces up like ladies.
Check out that Skittles bitch man, I've been in here so long she's startin' to look pretty good.
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2. n. (vulgar) A derogatory term for female who is annoying, rude, and tends to wear wears multi-colored clothing.
Red, White, Blue and Orange? Look at that tacky skittle bitch over there.
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Another word for paracetamol tablets or aspirin taken to relieve a headache or other ailment which is too minor to warrant it.
"Put down the bitch skittles brad, you only had 2 beers last night! "