bitter tits

Bitter tits is usually when someone is all uppity and bent out of shape about something for a dumb reason or even a valid reason. This can specially apply to females since they usually get angry over very trivial and dumb shit, but this phrase is not gender specific and can be used for any situation that calls for it.

Melvin: "Hey, look at that dog shitting in my laundry hamper?"
Larry: "Don't get all bitter tits about it, at least it's the dirty clothes hamper!"