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Chloro(2-thienylmethyl)magnesium

Chloro(2-thienylmethyl)magnesium, or TP-MeMgCl, or 2-thiophenylmethylmagnesium chloride is made from 2-(chloromethyl)thiophene. It's a grignard reagent and an intermediate that can be reacted with acetonitrile to form TP2P (ThioPhenyl-2-Propanone). Then Molecular Formula
C5H5ClMgS
Average mass
156.916 Da
Monoisotopic mass
155.965088 Da

Tony: I synthesized Chloro(2-thienylmethyl)magnesium by reacting 2-(chloromethyl)thiophene with magnesium turnings in diethyl ether. I replaced the diethyl ether with dibutyl ether and reacted it with acetonitrile and hydrolyzed it with hydrochloric acid to yield TP2P (ThioPhenyl-2-Propanone)

by CognitiveFuel September 11, 2023