Driving my nuts

To turn a guy on, either by looking attractive or stimulating their mind in one way or another.

Girl: Hey, look at my new dress Frank.
*girl undresses in front of him, is wearing sexual underwear*
Frank: Dayam girl, you're driving my nuts!
*girl slaps Frank*

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Guy one: So there's this new girl Paula that I'm really in love with.
Guy two: Oh yeah? Is she driving your nuts?
Guy one: She sure is.
Guy two: Nice one. I hope that works out!

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Driving me up my nuts

Conflation of the expressions drive me up a wall and driving me nuts. Basically when someone is annoying you so intensely it's almost like they're kicking you in the balls. Hence the reference to the word "nuts."

Co-worker: How's the project with Amy coming along?
Me: Holy moly ... she's really driving me up my nuts. I can't stand her constantly changing her mind about everything.