A term used commonly in early stage startups.
An act of mass destruction and typically used by one of the founders, it refers a sudden and disruptive request that invalidates one or more large sets of in progress work that relied on previously assumed to be valid information prior to the request being made.
"We had already started the project, then Brian our CEO throws in a Founder Grenade about an idea he had at the while at gym so we need to throw all the work away and start from scratch again."