1. When somebody has taken advantage of your good nature for the last time.
2. When somebody has repeatedly taken the piss, disrespected or insulted you, or somebody close to you, to the point that you no longer wish to associate with them.
Doreen: "How come you don't speak to them anymore?"
Margery: "Fuck them, they've shit their hole full."
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I ended up sitting on a plane next to a guy with a face like a fist full of ass holes.
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Noun: When a person, specifically an old, crusty gym dude, casually walks around nude in the locker room and decides to bend over in front of you, exposing his asshole.
Friend: Yo, what the fuck? Did you see that?!
Me: Yea bro, he just gave you the full hole!