Def 1:
A Spackler of Gananches is a person who gets laid a lot
Def 2:
a half insult half compliment for a friend who has done something sneaky/unusual/funny
Tyler: Mike, what's your secret?
Mike: I dunno man, i'm just a Ganache Spackler
Connor: I just stole a decorative autumn squash from an industrial greenhouse.
Geoff: Connor, you're such a Gananche Spackler.