HSD

an acronym, commonly used on the Internet, meaning "holy shit, dude", derived from the infamous South Park feature film, 'South Park: Bigger, Longer, & Uncut' quote - Kyle Broflovski

Mr. Garrison: What did you say?!
Eric Cartman: Oh, I'm sorry, I'm sorry. What I said was: How would you like to SUCK MY BALLS, Mr. Garrison?
Kyle Broflovski: Holy shit, dude(HSD)...

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HSD

High Sex Drive.
Normally owned by males who masturbate to much. Can end in death of their girlfriend.
Unless the girl has it too...

Boy: Come here, *Grunts* Ooooh more.
Girl: Fuck stop that hurts!
Boy: You like it!
Girl: Stop! You have HSD...

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HSD

Acronym for 'hardcore street drugs'. Usually means heroin, crack, meth, etc.

Yo, let me get some of those HSDs!

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hsds

Holy Snapping Duck Shit - an exclamation of total surprise.

Holy snapping duck shit! When I posted hsds I didn't mean Hardcore Satan Death Sex

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HSD

Means “Hey Sugar Daddy”

Gigi:“HSD~”
Nathan:“WTAF!”