Have an issue, here's a tissue.

When you're crying, someone will kindly offer a tissue to wipe your tears on.

Tiffany: (lisping) ARRGH!! This Snapchat update SUCKS!! (cries)
Teacher: (gives Tiffany a tissue) You have an issue, here's a tissue.

Tiffany: *blushes*

Tiffany: (takes off her glasses, wipes her tears with the tissue, cleans her glasses with that tissue and then puts her glasses back on.)
Tiffany: (sniffles, blows nose on that same tissue)