A Highway Lizard, is a woman who will specifically target lifted 4x4's, semi trucks, or can be seen seductively dressed on the side of a road, with the hopes of attracting the attention of any guy who is willing to give her any sort of attention. You can always find a Highway Lizard at truck stops, gas stations, night clubs, or outdoor party spots.
Not to be confused with a Mud Cricket or a River Roach. But the Highway Lizard is closely related.
Hey Danny, were you out with that Highway Lizard last night.. Dude, get your pencil checked, cause she's been on every rig at Stave Lake.