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Holy Fuck Lois originated from a porn video somewhere on the internet. People are using it as a joke when a random funny video starts. People are starting to think that the r34 fandom is starting to takeover the internet. The term "Holy Fuck Lois" is used also in "shitposts" which are a combination of weird videos with weird sounds.
Ha, look at this video "Holy Fuck Lois, im cumming"
Ha funny
it is a filler spam word to use whenever you dont agree with something and wanna say something. alternatives can also be used such as, 'Holy fuck stewie im shitting'
(1) "bro why do you always ignore me when i speak and say random shit"
"holy fuck lois im cumming"
"holy fuck lois im cumming"