The feeling of intense heat on The Butthole. Sometimes this feeling can be so intense, it literally feels like you can fry an egg on The Butthole. Hot Asshole Syndrome is typically caused from a Raw Asshole due to constant wiping when dealing with Hiney Piss. Hot Asshole Syndrome can last for an entire day or longer if not dealt with properly.
Clyde was dealing with an intense case of Hiney Piss and ignored the recommendation from his peers to wipe his butthole with Wet Wipes. He then came down with Hot Asshole Syndrome and was waddling around in a miserable state of mind.