Annoyed, unhappy, or bored, especially with a situation that has existed for a long time.
I'm fed up with your lie.
He is fed up with this new reality.
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A term used to describe that someone is sick and tired of anyone's shit.
Guy 1: JOE MAMA IS SO FAT, UGLY, AND STUPID!!!!! HAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHA!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Guy 2: OH MY GOD! I'M FED UP WITH YOU AND YOUR SHIT!!!!!!!!!!!!