I don't give two and a half shits

You really, REALLY don't care about what someone just told you.

Brody: Hey, I just found this really funny video I wanna show you, it's about this-

Ryan: I don't GIVE two and a half shits, alright?!

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I don't give two and a half shits

Combining a reference to two and a half men and the fact that you care so little about what the other person's saying.

-Hey, guess what I was doing last night?
-You know what? I don't give two and a half shits!

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