An expression, when said, means you really do not care about what someone is saying, or what's going on around you. Recommended to be said sarcastically.
Shithead Neighbor: Hey Tim!
You: Yeah, hi.
Shithead Neighbor: I won the lottery jackpot yesterday! 40 million dollars for me!
You: Well guess what? I don't give two shits if you win 40 million, or 40 cents. Get the fuck out of my face please.
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Way of saying, I really could care less for this shit, and shut the fuck up. Wrapped up in one little phrase.
Dude #1: Hey, can you go water my plants while I'm gone?
Dude #2: I don't give two shits about your damn plants!
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