Interstate 10

The most rural Interstate (except maybe I-8). Between San Antonio and Los Angeles, I-10 is either in a large town or in absolute nothingness. It has an intersection with I-20 in the middle of nowhere in Texas, 130 miles from El Paso and 450 miles from San Antonio.

Of somewhat interest is "The Thing". I myself do not know what that is but it is located near Texas Canyon, Arizona, on I-10.

I-10 passes through these major cities:

Los Angeles, Phoenix, Tucson, El Paso (even though nobody would put it on this list), San Antonio, Houston, New Orleans, and Jacksonville.

"Wanna go see The Thing?"

"Where's that?"

"Nowhere, Arizona, on I-10"

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