1. Having played too much Jenga for one sitting
2. Tired/wiped out of any activity
3. Jacked up on any substance to a non-participatory degree
"Another game?"
"Nah, dude, I'm Jenga'd out for now."
"Yo, Andrew, want another shot?"
"Dude, I think Andrew's Jenga'd out...let's draw penises upon him."