Jesse what the fuck are you talking about

A statement that can be made when one around you says something that is complete nonsense, like excessive usage of modern internet slang or memes in regular conversation, or can be used in response to incomprehensible subjects.

Originated from voice edits of Jesse Pinkman and Walter White from Breaking Bad in diners

Jesse Pinkman: Yo Mr. White, did you hear that the new egirl bussy was a doomer based cuck?

How about the time he was ratioed in 4k because he was down bad, fr, on God.
Walter White: Jesse what the fuck are you talking about?