Jesus Christ on a bicycle

The using of christ's name, not necessarily in vain, but to exclaim surprise, disbelief, or disgust.
Also used in the excellent film, Ginger Snaps.

'Jesus Christ on a bicycle, Bob! You gave me a fright!'
or
'Jesus Christ on a bicycle! That was soooo gnarly!'

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Jesus Fucking Christ on a Bicycle

Interjection indicative of trouble, something wrong

"Jesus fucking Christ on a bicycle! Slow down, but don't stop." Mr. Wednesday in Neil Gaiman's American Gods, Part 2, Chapter 12.