An adjective describing someone who is so fugly or slutty that no decent guy wants to fuck them.
Instead of pursuing the fugly/whorish person the guy 'zips up his Johnson' at all costs.
Girl: 'Do you see that hoe making an ass out of herself? She is trying so hard but she's so ugly that no one will give her a chance.'
Other girl: 'Yeah, she's a total Johnny Zipper.'