Originally used by Hannah Gadsby in her netflix stand up comedy special, “Douglas”. The joke first started with Hannah saying how different things would be called if women were allowed to name them. She also says, “Men, how would you like it if we called your balls Karen’s handful? Not very much.” And “If a man starts getting moody it’s because karen’s giving them a squeeze”
His Karen's Handful must’ve been squeezed really hard since he’s acting like a jerk.