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A woman with Lady Gaga Syndrome is a woman who looks really attractive in some photos's but then ugly in others.
Guy 1: Hey man, look at Megan Fox, she's so hot.
Guy 2: Really hot. Too bad she has Lady Gaga Syndrome.
Guy 1: What?
Guy2: Y'know, sometimes Megan Fox looks really attractive in some photos, and then others looks like she has nothing but a plastic make up face on. Half fugly, half hot.
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When a celebrity can easily look like a completely different person in a different picture, scene, or setting.
Person 1: Who is that guy that plays Sirius Black?
Person 2: Gary Oldman
Person 1: Well then who plays Commissioner Gordon in the Bale Batman movies?
Person 2: Also Gary Oldman, he has Lady Gaga Syndrome.