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An insult. Similar to telling someone to Get lost, Get real, stop being silly, that's rediculous etc...
Lose life Brad, I'm not going on a date with you!
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To make a social blunder so bad, you drive away your friends, lose a great opportunity, become infamous, or an otherwise unpleasant consequence of a seemingly in consequent action
Person: I thought he would accept me, so I told him I want to create weapons of mass destruction when I grow up. Now, he's disturbed by me.
Person's mind: You lose at life.