When you force your political beliefs onto your website, and use your power as the founder to unfairly persecute those who disagree with you.
Mark Zuckerberg Syndrome be like:
"Howdy y'all, I'm Mark Zuckerberg."
"As you may know, I am a flaming liberal. If you're not, and I find out, YOU'RE GETTING KICKED OFF MY WEBSITE, YOU SON OF A BITCH!"
"....So anyway, I heard you were interested in toilets..."
When a guy who's professionally and financially successful dates or marries an ugly girl.
He makes six figures at a technology company but have you seen his girlfriend? She's fugly. He has a case of Mark Zuckerberg syndrome!
People that need someone else to live, survive and function normally.
Universities create these people that need people to do everythig for them, they have Mark Zuckerberg syndrome.