Mista Big Bob is a strain/brand of K2 Spice that was popular in the southern united states in the late 2000s. Its packaging featured an image of gangster spongebob holding a wad of money and wearing a luxurious pimp outfit. It was notoriously potent and caused several hospitalizations, with several users experiencing convulsions, muscle spasms, and stuttering after smoking a small amount.
Dwayne: fuck school nigga, blow mista big bob