Said sarcastically after a situation you don't like but feel the need to say something to alleviate frustration.
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Without the sarcasm it can also be used to show approval or as a compliment.
Mike: Dude, your girlfriend totally ditched us at the bar.
Me: Nice. Real Fuckin Nice.
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Stripper: hey cutie, I want to give you a lap dance and rock your world!
Me: Nice. Real Fuckin Nice.
Jealous Mike: What? Where's my lap dance?? Nice. Real Fuckin Nice.
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