Used for when something surprises you or goes especially wrong or bad. You can say it in a light matter, jokingly, or further emphasize the two as separates making a more serious and powerful oofson.
Sarah: “I spilled water on myself in my sleep”
Katie: “oofson”
ex 2:
Reagan:” did you hear Marygrace cheated on John?”
Caelan: Oof.SON.