Being so wrapped up in nostalgia for the past that you can not see or be a part of the current or future world.
Joe-24: See how he sit in that rocking chair, staring at nothing even though the hypnotron is on?
Jeb-16: Leave old #3 alone, Joe. He's just thinking about when food didn't come in squeeze tubes.
J-24: Haha, food always came in squeeze tubes! ...didn't they?
J-16: ...dem Old World Blues.
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The term is used to describe a form of depression and anxiety, manifesting as an unhealthy obsession with the Old World. The blues cause the affected person to distance themselves from the world around them, withdraw from society, and become apathetic.
Doctor Mobius: "There is an expression in the Wasteland: "Old World Blues.""
Doctor Klein: "It refers to those so obsessed with the past they can't see the present, much less the future, for what it is."