A person's ass that is full of pimples and/or pockmarks; similar to how kids with acne were called "pizza`face" back in grade school, except this term is specific to the buttock area.
Matt: "Alex mooned me yesterday and I was like, 'damn! I didn't order no pepperoni & butthole pizza!'"
Cara: "Ha! I called him up and ordered it for you and he said he'd deliver for free."
Matt: "Well, there was way too much pepperoni for my liking."
Cara: "Yeah, and probably not enough butthole, huh? ha!"
Matt: "SIIIIIIICK!!!!"
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When a person 's face receives multiple rounds at close range from a rifle and the muzzle flash chars the skin and combined with the kinetic induced pepperoni facial holes, produce a perfect image of a PIZZA BUTTHOLE
Damn Rich. You mag dumped on this mother f*cker like a Brooklyn street enforcer, sheeit, his face looks a cratered ham Dawg, it be worse even bro, dat mofo bitch is stank and lookin like a pizza butthole.
Damn man. Dat Puzza hut nigga got a hold in his face. Pizza butthole